Bacteria and fungi produce a variety of different compounds to communicate with each other, to fight one another or to survive in ecological niches. Some of these molecules are also of great use for humans, e.g. as antibiotics or as chemotherapeutics. The variety of microorganism species on earth is immense and many of them are still unexplored. Their genome can be read like a map to understand which molecules are produced and how. This helps us to understand their function for the organism as well as its possible use in the human sphere. We show how we hunt for natural products treasures by using microbiological and molecular biology methods to explore the world of microbes.