Discovery of Prehistoric Microbes and Their Natural Compounds
In our lab, we examine archaeological samples—such as dental calculus—from which we aim to extract natural compounds that could be used as antibiotics. Thanks to their exceptional state of preservation, such samples provide access to genetic material from microorganisms that lived many centuries or even millennia ago!
Using state-of-the-art extraction and sequencing methods, it is now possible to study the evolution and properties of these organisms through bioinformatic analysis. Through a process known as “genome mining,” we can search their DNA for genes responsible for the production of bioactive molecules. Such genes can be genetically engineered into modern microorganisms to discover new and interesting natural compounds. These natural compounds help us learn more about the evolution of bacteria and find new antibiotics.
We’re opening the doors to our lab for you and inviting you to see how we unlock the secrets of these ancient microorganisms.
